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Vildagliptin

Vildagliptin

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Vildagliptin

Ball-and-stick model

Clinical data

Trade names

Galvus/Gliptus

Synonyms

(2S)-1-{2-[(3-hydroxy-1-adamantyl)amino]acetyl}pyrrolidine-2-carbonitrile

AHFS/Drugs.com

International Drug Names

Routes of
administration

Oral

ATC code

¬∑†††††††† A10BH02†(WHO)
A10BD08†(WHO) (with†metformin)[1]

Legal status

Legal status

¬∑†††††††† UK:POM†(Prescription only)

Pharmacokinetic†data

Bioavailability

85%

Protein binding

9.3%

Metabolism

Mainly†hydrolysis†to inactive metabolite;†CYP450†not appreciably involved

Biological half-life

2 to 3 hours

Excretion

Renal

Identifiers

IUPAC name[show]

CAS Number

¬∑†††††††† 274901-16-5

PubChemCID

¬∑†††††††† 6918537

IUPHAR/BPS

¬∑†††††††† 6310

DrugBank

¬∑†††††††† DB04876Yes

ChemSpider

¬∑†††††††† 5293734Yes

UNII

¬∑†††††††† I6B4B2U96P

KEGG

¬∑†††††††† D07080Yes

ChEMBL

¬∑†††††††† CHEMBL142703Yes

ECHA InfoCard

100.158.712Edit this at Wikidata

Chemical and physical data

Formula

C17H25N3O2

Molar mass

303.399 g/mol

3D model (JSmol)

¬∑†††††††† Interactive image

Solubility in water

Freely Soluble in water†mg/mL (20†¬įC)

SMILES

InChI

Vildagliptin†(previously†LAF237, trade names†Galvus,†Zomelis,) is an oral anti-hyperglycemic agent (anti-diabetic drug) of the new†dipeptidyl peptidase-4 (DPP-4) inhibitor†class of drugs. Vildagliptin inhibits the inactivation of†GLP-1[2][3]†and†GIP[3]†by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas.

Vildagliptin has been shown to reduce hyperglycemia in†type 2 diabetes mellitus.[2]

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